At Fraunhofer IWS implant materials are equipped with micro and sub micrometer structures by direct laser interference patterning (DLIP). This research aims at the improvement of the interaction between implant and biological system to accelerate the wound healing after implantation and improve the efficiency of the artificial component.
For this purpose titan, a typical material for implants was patterned with periodic micro lines using two beam interferences. The periodicity varied from 3 µm to 20 µm with just altering the overlap angle of the two laser beams. Following, the cleaned and sterilized surfaces were colonized by human mesenchymal stem cells (hMC) at the Max Bergmann Center of Biomaterials at TU Dresden.
After 24 h a directional growth of cells was detectable. Up to 65 % of the seeded cells had oriented strongly to the micro lines. This tendency remained over several days of cell growth (proliferation) so that Cell Guidance, caused by the topography, occurs. In this way functionalized implants are more likely to be accepted and integrated by the human body.
Furthermore, with DLIP technology complex element geometries can be processed. Thus it is possible to equip endoprostheses such as dental implants, artificial hip or knee joints with functional topographies.