Products and projects

Development of a tubular perfusion micro-bioreactor system as a platform for cell cultures

3D-Scaffold-Printer mit beheizbarem Mehrkanaldosiersystem
© Fraunhofer IWS Dresden

3D scaffold printer with temperature-controlled multi-channel metering system

Schematic representation of the perfusion micro-bioreactor system
© Fraunhofer IWS Dresden

Schematic representation of the perfusion micro-bioreactor system

3D tubular-fiber cell carrier
© Fraunhofer IWS Dresden

3D tubular-fiber cell carrier

The challenge in growing complex tissue cultures is to integrate channels for supplying oxygen and nutrients for maintaining the 3D biological micro-environment.

Principle of operation

The multi-organ chip platform is the foundation of a novel perfusion micro-bioreactor system for culturing different tissues within a common circulation system that facilitates characterizing the interactions between them.

The development of vascularized 3D tissue constructs can be accomplished via three-dimensional organ printing. The employment of specialized cellular matrix composites enables tiny permeable tubular fibers to be produced that act as three-dimensional structural supports for cells and simultaneously function as artificial blood vessels.

The interface between the tubular fibers and the micro-bioreactor system enables media to be supplied to the cells via the circulation system of the perfusion micro-bioreactor.

Applications

This advanced technology platform provides a new, high-performance tool for research and development in the field of tissue reconstruction, investigation of pharmaceutical drugs, and conducting cytotoxicity studies.